Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2629-34. doi: 10.1016/s0960-894x(98)00490-9.

Abstract

The synthesis and pharmacological profile of a novel series of potent and selective phosphodiesterase type IV (PDE IV) inhibitors is described.

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / antagonists & inhibitors*
  • Amides / chemical synthesis
  • Amides / pharmacology
  • Animals
  • Anti-Asthmatic Agents / chemical synthesis*
  • Anti-Asthmatic Agents / pharmacology*
  • Carboxylic Acids / chemical synthesis
  • Carboxylic Acids / pharmacology
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Eosinophilia / drug therapy
  • Guinea Pigs
  • Phosphodiesterase Inhibitors / chemical synthesis*
  • Phosphodiesterase Inhibitors / pharmacology*
  • Quinolones / chemical synthesis
  • Quinolones / pharmacology
  • Structure-Activity Relationship

Substances

  • Amides
  • Anti-Asthmatic Agents
  • Carboxylic Acids
  • Phosphodiesterase Inhibitors
  • Quinolones
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Cyclic Nucleotide Phosphodiesterases, Type 4